I hope that the evaluation framework introduced in the paper can become used by other researchers working on mutational signatures.
There is a numerical benchmark reported in Fig. 4 with absolute runtimes and memory usages that can directly be reproduced with the provided source code. The benchmark was performed on the author's computer, and since numerical performance and parallel scaling can be somewhat hardware-dependent, it would be of interest to see whether a performance that is comparable to the one reported in the paper can be reproduced by others on their own computers in practice. The benchmark simulates a growing tissue from one to 10,000 cells in just ten minutes, so this offers an easy entry point into tissue modeling and simulation. No input data is needed to reproduce the output. The program has no dependencies.
The method is trained on the data that were available, but it is meant to be re-trainable as soon as new data are published. It would be great to be really sure that even someone else will be able to do it. In case we receive any feedback, we would be really happy to improve our Github repository so as to make the reproduction easier!
