I hope that the evaluation framework introduced in the paper can become used by other researchers working on mutational signatures.
This is a seminal paper on reproducibility in cancer biology. It should be a gold standard for reproducible research work. Therefore, it should be attempted to reproduce it. Supposedly, this will be pretty easy to reproduce and can be used as a *positive control* in repro hacks!
The method is trained on the data that were available, but it is meant to be re-trainable as soon as new data are published. It would be great to be really sure that even someone else will be able to do it. In case we receive any feedback, we would be really happy to improve our Github repository so as to make the reproduction easier!