Metadata annotation is key to reproducibility in sequencing experiments. Reproducing this research using the scripts provided will also show the current level of annotation in years since 2015 when the paper was published.
This was my third attempt at making a paper fully reproducible. To date I it's the most reproducible that I have published. I'm interested to know what stumbling blocks exist that I'm not aware of (aside from needing software like ArcGIS to fully rerun the complete analysis).