A comprehensive comparison of tools for fitting mutational signatures


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Submitted by 8medom

June 28, 2024, 12:48 p.m.

A comprehensive comparison of tools for fitting mutational signatures

Matúš Medo, Michaela Medová
Matúš Medo, Michaela Medová, A comprehensive comparison of tools for fitting mutational signatures, arXiv:2310.01562, 2023
DOI:  10.48550/arXiv.2310.01562        

Brief Description
This paper uses synthetic data to compare various tools for fitting mutational signatures. It is written in Python with some tool scripts (a few lines long) in R.
Why should we reproduce your paper?
I hope that the evaluation framework introduced in the paper can become used by other researchers working on mutational signatures.
What should reviewers focus on?
Some tools take a long time to run (e.g., mmsig, signature_tools). It is better to evaluate a fast tool such as MutationalPatterns or SPA (SigProfilerAssignment), the code can be then run on a common computer.

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